Document Details
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Document Type |
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Thesis |
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Document Title |
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Biopolymer for Bone Grafting and Bone Cement مبلمر حيوي لترقيع العظام وتقويتها |
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Subject |
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Bone grafting. |
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Document Language |
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English |
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Abstract |
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Bone generally has the ability to regenerate completely but requires a very small fracture space or some sort of scaffold to do so. Synthetic biodegradable bone grafts have been used for bone regeneration. Cements based on synthetic calcium sulfate and/or calcium phosphate are among the most investigated materials for dental and orthopedic applications in reconstructive surgery. To overcome the short-term cytotoxic effect, brittleness and fast resorption of calcium sulfate dihydrate (CSD), as bone substitute material, SCD was doped with Lepidium sativum water extract (LS) powder and mixed with cow bone mineral (BM) (1: 0.04: 1: wt/wt ratio respectively). The FTIR and Raman spectra of BM-CSD, BM-CSD-LS, and BM-LS composites, compared to BM, were recorded. LS was analyzed by using GC/MS and SEM-EDX. The compressive strength of the tested composites were also examined by DMA and recorded. The crystallinity of bone mineral, the apatite crystal size, the variation in the carbonate to phosphate ratio, the dissolving time and the acid phosphate content were calculated. The results revealed that the total carbonate/phosphate ratio, type B-carbonate substitution, and acid phosphate content increased dramatically in all tested composites, the maximum increase was detected in BM+CSD+LS composite. Other forms, rather than B-carbonate substitution, takes place such as substitution with Zn, Mg and amino acids. The BM-crystallinity (BMC) decreased significantly in both BM+CSD, B+CSD+LS while, it is slightly decreased in BM+LS composite compared to BMC. The compressive strength of BM+CSD+LS composite increased 1.5 fold together with a dramatic increase in the dissolving time compared to the other tested composites. Thus, addition of CSD to bone mineral leads to decrease in crystallinity while adding LS only or doping CSD with LS increases the crystallinity of bone mineral compared to BM+CSD composite with increasing in the apatite crystal size, the acid phosphate content, the dissolving time and the compressive strength as well. |
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Supervisor |
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Gehan Abdel Raouf Ahmed |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1434 AH
2013 AD |
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Number Of Pages |
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95 |
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Co-Supervisor |
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Hana Mohammed Gashlan |
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Added Date |
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Wednesday, September 11, 2013 |
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Researchers
| هند مصلح الجابري | Al-jabbri, Hind Musleh | Investigator | Master | |
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