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Document Type |
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Thesis |
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Document Title |
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Effect of Pomegranate Juice on Lipid Profile and Antioxidant Enzymes in Hypercholesterolemic تأثير عصير الرمان على صور ليبيدات الدم والإنزيمات المضادة للأكسدة لدى الفئران المصابة بارتفاع الكولسترول |
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Subject |
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Rats Diseases |
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Document Language |
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English |
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Abstract |
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Objective: The present study was carried out to investigate the effects of oral
administration of Pomegranate juice at three dosage levels (1, 3 and 5 ml/kg b. wt.) to
hypercholesterolemic rats for 28 days on body weight gain %, feed efficiency ratio,
relative weights of some internal organs, serum levels of total cholesterol (TC),
triglycerides (TG), lipoprotein fractions and liver enzymes, aspartate aminotransferase
(AST) and alanine aminotransferase (ALT) were performed. Antioxidant enzymes,
catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx,) were
determined in homogenate liver. Histopathological examination of liver and heart were
also carried out.
Methods: Thirty five male Wistar rats were distributed into five equal groups as
follows: negative (normal rats), positive (hypercholesterolemic rats) control groups and
positive groups orally given Pomegranate juice in doses of 1, 3 and 5 ml/kg b. wt.,
respectively. Results: The results showed that oral administration of Pomegranate juice
to hypercholesterolemic rats for 28 days significantly decreased serum levels of TC, TG,
low density lipoproteins cholesterol (LDL-c), very low density lipoproteins cholesterol
(VLDL-c) and liver enzymes when compared to the control positive group. Levels of
high density lipoprotein cholesterol (HDL-c) and antioxidant enzymes were significantly
increased as compared to the control positive group. Histopathological examination of
liver and heart of Pomegranate juice-treated groups showed amelioration of histological
changes caused by high level of cholesterol in the positive control group. Conclusion:
Results indicated that Pomegranate juice produces potent antiatherogenic and
antioxidant effects in hypercholesterolemic rats. This study recommends that drinking
Pomegranate juice may be beneficial for patients who suffer from hypercholesterolemia
and/or arteriosclerosis. |
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Supervisor |
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REHAM ABO ALMAHASEN ARAFAT |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1434 AH
2013 AD |
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Number Of Pages |
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107 |
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Co-Supervisor |
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AMANI ALIOI Al-RasheediI |
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Added Date |
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Tuesday, September 17, 2013 |
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Researchers
| منال معلا المروعي | Al-Moraie., Manal Moalla | Investigator | Master | |
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