Document Details

Document Type : Thesis 
Document Title :
Hepatoprotective Effect of Chamomile Capitula Extract against 2, 4-Dichlorophenoxyacetic Acid- Induced Hepatotoxicity in Rats
التأثير الوقائي الكبدي لمستخلص الكاموميل على الفئران المصابة بالتسمم الكبدي بـ2و4 داي كلورو فينوكسي استيك اسيد
 
Subject : Rats--Effect of chemicals 
Document Language : English 
Abstract : Abstract Objective: The present study was carried out to investigate the effect of oral administration of aqueous extract of Chamomile capitula extract for 4 weeks on hepatotoxicity induced to rats by herbicide 2, 4-Dichlorophenoxy acetic acid (2, 4 D). These effects could be explored by measuring body weight gain, feed efficiency ratio and relative weight of the liver. Serum levels of liver enzymes; aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP); albumin, total protein, total bilirubin, lactate dehydrogenase (LDH) enzyme and antioxidant enzymes; glutathione reductase (GR) and superoxide dismutase (SOD) were determined. Histopathological examination of liver was also performed. Methods: Thirty six male Wistar rats were allocated into six groups as follows: - Group1: negative (normal rats) control; Group 2: positive (hepatotoxic) control given accumulative dose of 75 mg/kg b.wt., of 2, 4- D; Group 3: Positive (hepatotoxic) control given accumulative dose of 150 mg/kg b.wt., of 2, 4-D; Groups 4: given orally Chamomile capitula extract in a dose of 500 mg/kg b.wt., alone. Groups 5 and 6: given combination of Chamomile capitula extract with either the accumulative doses of the 75 mg/kg b.wt., or the 150 mg/kg b.wt., of 2, 4-D. Results: The results showed that oral administration of Chamomile capitula extract to hepatotoxic rats for 28 days significantly decreased the elevated serum levels of liver enzymes (AST, ALT and ALP), total bilirubin and lactate dehydrogenase enzyme and increased serum total protein, albumin, when compared to the corresponding control positive groups. Levels of antioxidant enzymes glutathione reductase and superoxide dismutase were significantly increased as compared to the control positive groups. Histopathological examination of liver sections of rats administered Chamomile capitula extract showed alleviation of histological degenerative changes caused by 2, 4-D herbicide. Conclusion: The results suggest that Chamomile capitula aqueous extract induces potent hepatoprotective and antioxidant effects in 2, 4 D - hepatotoxic rats. This study recommends that intake of Chamomile capitula extract as a herbal tea may be beneficial for patients who suffer from liver diseases and oxidative stress. 
Supervisor : . Reham Abu El mahasen Arafat 
Thesis Type : Master Thesis 
Publishing Year : 1434 AH
2013 AD 
Number Of Pages : 80 
Co-Supervisor : Thanaa Abdel Fattah Ali El-Kholy 
Added Date : Wednesday, September 18, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
دلال عبد العزيز Al baroudiالبارودي, Dalal Abdul AzizInvestigator  

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